Gene information
Official symbol SERPIND1
Official full name serpin family D member 1
Gene type protein-coding gene
Chromosome22q11.21
Alias symbolHC-II; HLS2; HC2; D22S673
Previous symbolHCF2
Gene familySerpin peptidase inhibitors
Resources
Entrez Gene 3053
HGNC HGNC:4838
Ensembl ENSG00000099937
Vega OTTHUMG00000150755
UCSC uc002ztb.2
GO terms: 26 records
GO Description Category LogP Number of genes Detail
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004867 serine-type endopeptidase inhibitor activity GO Molecular Functions -8.20238048 12 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
sulodexide agonist TdgClinicalTrialTEND 12818259 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
heparin cofactor 2 proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Huang SS et al. Coron Artery Dis. 2008
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